.380 probably shouldn’t be your #1 choice given the availability of something more powerful and the ability to dress properly to conceal it, but that isn’t always how life works. You cannot (or at least should not) base your life, all of your clothes, or your entire personality and existence around concealed carry. I had never carried anything smaller than 9mm until I got my S&W Bodyguard 2.0 and it really changed my perspective.
I wanted to be able to go on walks and carry and I wanted to wear sweatpants or gym shorts while I did it…and I wanted something that could be put in my pocket or clipped beltless than wasn’t a burden and didn’t weight down my pants. I bought the Bodyguard 2.0 and fell in love with it…small and light, but still fits my hand well and can actually be aimed and shot comfortably. Comparable sized 9mm (like the P365 or Hellcat) are still bigger, double the weight, and, while not unbearable, aren’t exactly fun to shoot in any way. And something like the 442/642 is thicker, heavier, shorter barrel but bigger, awful “sights”, awful trigger, and 5 rounds.
Like someone else said, it’s about trade offs. A small .380 or a LCR in .22lr loaded with Federal Punch is better in your pocket while you run down to Shell to get gas for your lawn mower than your Glock 19 at home on your dresser because you’re in gym shorts. Or even if you have on jeans and a belt and just want to go eat dinner being comfortable 16 ounces is always going to be more comfortable than 30+. Some people want to carry the biggest gun they can all the time with extra mags and that’s fine, but if you go with odds and practicality you’re never, ever, ever going to pull or use your gun in self defense and even if you do the threat is not going to be expecting rounds coming at him at all. Whatever you have in you should be adequate. And this doesn’t even go into discussions about people who have trouble shooting larger calibers or maybe don’t have the strength to chamber a semi-auto round. If all you can load and shoot well is a .22lr than get something reliable, load it with good ammo, and carry it proudly.